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\section{Rationale}  When an MS patient is first diagnosed, the physician has no way of knowing if fine motor function will be impaired. As the disease progresses, the lesions seen in an MRI scan are no more informative of this prognosis. Advanced structural imaging methods, such as diffusion imaging, better tracks disease progression, but there is more that needs to be explained. Functional metrics may bridge the gap between structural damage, clinical disability, and disease progression. Identifying patients that are better able or unable to adapt to structural damage may lead to more personalized treatments. Identifying functional network metrics that are biomarkers with prognostic value could lead the way towards more effective treatements treatments  of MS.