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\section{Math}   \hspace{20 mm}Each tumor was modeled as a self-avoiding polygon (SAP). A SAP is a closed shape whose perimeter consists of a random walk path which does not visit the same site more than once, or a self-avoiding walk (SAW). A SAW of length $N$ in a $2$-dimensional lattice ${\Bbb R}$, starting at point $x$, is defined as a path $ω=(ω_0, ω_1, ..., ω_n)$, where $ωj ∈ {\Bbb R}$, $ω_0=x$, $|ωj − ωj−1| = 1$, $j = 1, 2, . . . , n$, and $ω_i /= ω_j$ for $i 6= /=  j$, and $0 ≤ i < j ≤ n$. ${\rm \!Z}^d$  starting at x, is defined as a path ω = (ω0, ω1, . . . , ωn) with ωj ∈ Z