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\noindent Our implementation ships as a library for IR manipulation, and we present a preliminary experimental study of our technique in TinyVM, a proof-of-concept virtual machine for run-time IR manipulation and compilation based on MCJIT. We then present a case study on the integration of our technique in McVM~\cite{chevalier2010mcvm}: we show the potential of our approach by enabling an aggressive specialization mechanism for the {\tt feval} construct - a source of bottlenecks in many MATLAB programs - that could not have been implemented using extant OSR techniques.  \paragraph{Structure of the Paper} Paper.}  The remainder of this paper is organized as follows. In Section~\ref{se:approach}, Section~\ref{se:overview}  we present our OSR technique and in Section~\ref{se:osr-llvm} we  outline its implementation and Application Program Interface (API) for VM builders. in LLVM.  Section~\ref{case-study} illustrates a case study in McVM. In Section~\ref{se:experiments}, we present the experimental study in TinyVM and discuss implications of inserting OSR points in a LLVM function, while inIn  Section~\ref{se:related} we discuss the state of the art of OSR in the literature and discuss addresses  related work. Section~\ref{se:conclusions} concludes the paper and presents some ideas for future research directions.