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\textbf{Table 2. Rescue of OS cockroaches with antibiotics after lethal dose of \textit{F. tularensis} LVS.}  Groups of OS cockroaches (n=8-18) were infected with approximately 100 LD_{50}s (between 1.3 x 10^6 CUF and 3.4 x 10^6 CFU) \textit{F. tularensis} LVS using sharpened pipette tips. Then at 2, 48, and 96 hours post-infection, infected cockroaches were treated by intrahemocoel injection (i.h.) or peroral feeding (p.o.) of the antibiotics indicated. Statistical differences in survival endpoints were determined by log-rank (Mantel-Cox) analysis using the 'survival' package in the R programming environment (version 3.2.1). analysis.  Asterisks indicate significant differences compared to the corresponding vehicle control group or alternative route of delivery (**=p<0.01, ***=p<0.001). ^{a}=this dose was administered three times during the study. ^{b}=survival outcome in the no manipulation group was not statistically different than survival in either vehicle control group (i.h. or p.o.; p>0.05 for all comparisons).