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\section{Abstract}  \textit{Francisella tularensis} is a zoonotic bacterial pathogen that causes severe disease in a wide range of host animals, including humans. Well-developed mouse models of \textit{F. tularensis} pathogenesis are available, but they do not meet the needs of all investigators. As a result, researchers are increasingly turning to insect model systems systems:  (1) to allow for throughput high-throughput  that would be cost prohibited cost-prohibitive  or ethically-questionable in mammals, mammals;  (2) to enable studies of host-pathogen interactions in situations where mammalian facilities are unavailable, unavailable;  and (3) to provide valuable information about environmental persistence and transmission. However, the utility of previously described insect hosts is limited because of temperature restriction, short lifespans, and concerns about the immunological status of insects mass-produced for other industries. Here, we present a novel host species, the orange spotted (OS) cockroach (\textit{Blaptica dubia}; Serville, 1839), that overcomes these limitations and is readily infected by \textit{F. tularensis}. Intrahemocoel inoculation of OS cockroaches was accomplished using standard laboratory equipment and lethality was directly proportional to the number of bacterial cells injected. Disease progression differed in insects housed at low and high temperatures, indicating that the model could be useful for dissecting both virulence and transmission pathways. As in mammals, \textit{F. tularensis} mutants lacking key components of the cell envelope or phagosomal escape pathway are attenuated in OS cockroaches. Finally, we examined the utility of this model in identifying antibiotics with \textit{in vivo} activity against \textit{F. tularensis}. Antibiotics were delivered by systemic injection or forced feeding; in the latter case, protection correlated with the oral bioavailability profile of each compound in mammals. Further, a developmental drug candidate with \textit{in vitro} activity toward \textit{F. tularensis} and \textit{Neisseria gonorrhoeae} failed to protect OS cockroaches from infection. Collectively, these results demonstrate that OS cockroaches are an important addition to investigators' tool box that should facilitate discovery of factors that control \textit{F. tularensis} virulence, immune evasion, and transmission while also providing a platform for early stage drug discovery and development.