Nathan edited subsection_Effect_of_textit_B__.tex  over 8 years ago

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\subsection{Effect of \textit{B. dubia} development on \textit{F. tularensis} virulennce} virulence}  Because insect immune responses are known to vary by age and developmental stage \cite{25730277}(other refs), we sought out to determine if there were any differences in susceptibility to infection in late instar juvenile cockroaches (as was used in all other portions of this report) compared to adult male and adult female cockroaches. We attempted to also evaluate susceptibility in early instar cockroaches, but these had significant number of animals die due to trauma and were, therefore, excluded from subsequent analysis. Injections in adults were performed using the same method described for the juveniles. We found that adult female and juvenile cockroaches had susceptibility patterns that were statistically indestinguishable from each other. But interestingly, we saw that adult male cockroaches were more sensitive to killing by \textit{F. tularensis}.