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Jason Huntley edited figures/Fig_Abx/caption.tex
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\textbf{Figure 7. Rescue of OS cockroaches with antibiotics after lethal dose of \textit{F. tularensis LVS}.}
Groups of OS cockroaches (n=???) were infected with 3.4 x 10^6 CFU \textit{F. tularensis} LVS and treated with
either vehicle controls
(A) (A; oral sucrose or injected PBS) or the indicated antibiotics (B-F) at 2, 48, and 96 hours post-injection. Solid blue lines indicate groups treated with oral antibiotics. Dashed black lines indicate groups treated by systemic injection.
(A) Control Statistical differences between groups
that were either injected with PBS or fed a sucrose solution without antibiotics all died within 7 days of infection. Streptomycin (B) and gentamicin (C) only were
protective when delivered systemically (p=0.00199 and p<0.001, respectively), but not when delivered orally. There is no statistical difference between route of antibiotic delivery for doxycycline (E) and ciprofloxacin (F). Resazurin (D), a dye that has been shown to have anti-\textit{Francisella} properties \textit{in vitro}, failed to prevent cockroach death determined by
either route. Kaplan-Meier
survival curves were compared by log-rank analysis.