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\textbf{Figure 6. Rescue of
B. dubia roaches OS cockroaches with antibiotics after lethal dose of
F. \textit{F. tularensis
LVS.} LVS}.}
Kaplan-Meier survival curves of OS cockroaches infected with
1.8 3.4 x 10^6 CFU \textit{F. tularensis} LVS and treated with
control solutions (A) or the indicated
antibioitc antibiotics (B-F) at 2, 48, and 96 hours post-injection. Solid blue lines represent groups treated with oral antibiotics. Dashed black lines represent groups treated by systemic injection.
There is no statistical difference between route (A) Control groups either injected with PBS or fed the sucrose solution without antibiotics all died within 7 days of
antibiotic delivery for doxycycline and ciprofloxacin. However, streptomycin infection. Streptomycin (B) and gentamicin
are only (C) were protective when delivered systemically
but not when delivered orally (p=0.00199 and p<0.001, respectively).
All OS cockroaches in the PBS injection control group died within 4 days. Feeding the sucrose solution alone, without antibiotic, extended the mean time to death but all...Sucrose solution alonethat did shows effectiveness of antibiotics after 106 CFU inoculation of F. tularensis LVS via systemic injection into B. dubia roaches. Antibiotics were administered 2, 48, and 96 hours post-infection either via systemic injection or oral administration. Roaches with There is no
antibiotic treatment resulted in 0\% survival after 4 days PI, while prolonged survival was observed in roaches treated with streptomycin delivered orally. Survival statistical difference between route of
over 80\% was observed in both groups treated with antibiotic delivery for doxycycline
(E) and
systemic injection of streptomycin. ciprofloxacin (F). Resazurin (D), a dye that has been shown to have anti-\textit{Francisella} properties \textit{in vitro} failed to protect by either route.