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\textbf{Figure 6. Rescue of B. dubia roaches OS cockroaches  with antibiotics after lethal dose of F. \textit{F.  tularensis LVS.} LVS}.}  Kaplan-Meier survival curves of OS cockroaches infected with 1.8 3.4  x 10^6 CFU \textit{F. tularensis} LVS and treated with control solutions (A) or  the indicated antibioitc antibiotics (B-F)  at 2, 48, and 96 hours post-injection. Solid blue lines represent groups treated with oral antibiotics. Dashed black lines represent groups treated by systemic injection. There is no statistical difference between route (A) Control groups either injected with PBS or fed the sucrose solution without antibiotics all died within 7 days  of antibiotic delivery for doxycycline and ciprofloxacin. However, streptomycin infection. Streptomycin (B)  and gentamicin are only (C) were  protective when delivered systemically but not when delivered orally  (p=0.00199 and p<0.001, respectively). All OS cockroaches in the PBS injection control group died within 4 days. Feeding the sucrose solution alone, without antibiotic, extended the mean time to death but all...Sucrose solution alonethat did shows effectiveness of antibiotics after 106 CFU inoculation of F. tularensis LVS via systemic injection into B. dubia roaches. Antibiotics were administered 2, 48, and 96 hours post-infection either via systemic injection or oral administration. Roaches with There is  no antibiotic treatment resulted in 0\% survival after 4 days PI, while prolonged survival was observed in roaches treated with streptomycin delivered orally. Survival statistical difference between route  of over 80\% was observed in both groups treated with antibiotic delivery for  doxycycline (E)  and systemic injection of streptomycin. ciprofloxacin (F). Resazurin (D), a dye that has been shown to have anti-\textit{Francisella} properties \textit{in vitro} failed to protect by either route.