deletions | additions       diff --git a/subsection_Antibiotic_rescue_To_explore__.tex b/subsection_Antibiotic_rescue_To_explore__.tex  index 3b97ff1..d5d4b05 100644  --- a/subsection_Antibiotic_rescue_To_explore__.tex  +++ b/subsection_Antibiotic_rescue_To_explore__.tex 
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\subsection{Antibiotic rescue} rescue of infected OS cockroaches}  To explore the drug whether OS cockroachs may be useful to model post-infection antibiotic  treatmentpotential of Blaptica dubia cockroaches, antibiotics were used in aims of curing roaches post inoculation of Francisella tularensis LVS. After infection  of 106 CFU of F. tularensis LVS, antibiotics were administered both systemically through hemocel injections, and orally through a sucrose solution. 100\% survival was observed after treatment \textit{F. tularensis} infection, we initiated disease  with systemic doxycycline, a high dose (10^{6} CFU) intrahemocoel challenge  and 90\% survival was observed with oral administration of doxycycline. Streptomycin prolonged survival of B. dubia roaches when then  administered orally, but 0\% survival was observed after 7 days of initial F. tularensis LVS inoculation. In contrast, 80\% survival antibiotics either by injection or by controlled feeding. Doxycycline, an antibiotic known to absorb well through mucus membranes,  was observed effective  when streptomycin delivered by either route. However, streptomycin, which does not readily cross mucus membranes,  was observed only effective  when injected directly into the hemocoel. Roaches treated orally with  streptomycin was delivered through showed  an intrahemoceol injection. increase in time to death but no change in overall survival compared to the control group that did not receive antibiotics (Figure 3).