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  \section{Abstract}    \textbf{Background.} \textit{Francisella tularensis} is a zoonotic bacterial pathogen that causes severe disease in a wide range of host animals, including humans. Well developed mouse models of \textit{F. tularensis} pathogenesis are available, but these systems do not meet the needs of all investigators. As a result, researchers are increasingly turning to insect model systems (1) to allow for throughput that would be cost prohibited or ethically-questionable in mammals, (2) to enable studies of host-pathogen interactions in situations where mammalian facilities are unavailable, and (3) to provide valuable information about environmental persistence and transmission. Previously described insect systems have been used to model \textit{Francisella} pathogenesis; however, the utility of these hosts is limited because of temperature restriction, short lifespans, and concerns about the immunological status of insects mass-produced produced for other industries. Here, we present a novel host species, the orange spotted (OS) cockroach (\textit{Blaptica dubia}; Serville, 1839), that overcomes these limitations and is readily infected by \textit{F. tularensis}. Intrahemocoel inoculation of OS cockroaches was accomplished using standard laboratory equipment and lethality was directly proportional to the number of bacterial cells injected. Disease progression differed in insects housed at low and high temperatures, indicating that the model could be useful for dissecting both virulence and transmission pathways. As in mammals, \textit{F. tularensis} mutants lacking key components of the cell envelope or phagosomal escape pathway are attenuated in OS cockroaches. Finally, we tested several examined the utility of this model in identifying anti-\textit{F. tularensis}  antibiotics for their ability to rescue OS cockroaches when with \textit{in vivo} activity. Antibiotics were  delivered systemically by systemic injection  or orally. Interestingly, forced feeding; in the latter case,  protection by related strongly correlated  with theknown  oral bioavailability profile of and the protective efficacy of several antibiotics prevented lethality when delivered systemically or orally, depending on the oral bioavailability profile. We also tested the ability of several antibiotics to rescue infected OS cockroaches when delivered systemically or orally.    \textbf{Results.} We found that OS cockroach lethality was directly proportional to the number of each compound in mammals. Resazurin, a compound with \textit{in vitro} activity toward  \textit{F. tularensis}LVS cells injected  and that virulence depended on the temperature of incubation. Bacterial mutants known \textit{Neisseria gonorrhoeae}, failed  to be attenuated in other host systems also were attenuated in protect  OS cockroaches. Interestingly, we observed robust extracellular growth during OS cockroach infections. Finally, we were able to distinguish effective antibiotics with favorable oral bioavailability cockroaches  from ineffective antibioitics and those with poor oral bioavailability.    \textbf{Conclusions.} These infection. Collectively, these  results demonstrate that OS cockroaches are an appealing alternative important addition  to mammalian or other insect models for evaluating investigators' tool box that should facilitate discovery of factors that control  \textit{F. tularensis} LVS pathogenesis. In addition, this model could be applied to virulence, immune evasion, and transmission while also providing a platform for early stage  drug development studies or vector-pathogen studies. discovery and development.