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\subsection{Antibiotic rescue of infected OS cockroaches}  To explore whether OS cockroaches may be useful to model post-infection antibiotic treatment of \textit{F. tularensis} infection, we initiated disease with a high dose (10^{6} (3.4 x 10^{6}  CFU) intrahemocoel challenge and then administered antibiotics either by injection or by controlled feeding (Figure 6). Doxycycline, an antibiotic known to absorb well through mucus membranes, was effective when delivered by either route. However, streptomycin and gentamicin, which have poor oral bioavailbility in mammals, were only effective when injected directly into the hemocoel. Ciprofloxacin failed to fully rescue \textit{F. tularensis} LVS-infected OS cockroaches at the dose given (1 ug), ug per roach),  which could result from differences in drug pharmacokinetics between insects and mammals. Resazurin, a dye molecule that has anti-\textit{F. tularensis} activity \textit{in vitro} \cite{24367766}, failed to protect OS cockroaches from infection.