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\textbf{Figure 6. Rescue of OS cockroaches with antibiotics after lethal dose of \textit{F. tularensis LVS}.}  Kaplan-Meier survival curves of OS cockroaches infected with 3.4 x 10^6 CFU \textit{F. tularensis} LVS and treated with control solutions vehicle controls  (A) or the indicated antibiotics (B-F) at 2, 48, and 96 hours post-injection. Solid blue lines represent groups treated with oral antibiotics. Dashed black lines represent groups treated by systemic injection. (A) Control groups either injected with PBS or fed the sucrose solution without antibiotics all died within 7 days of infection. Streptomycin (B) and gentamicin (C) were protective when delivered systemically but not when delivered orally (p=0.00199 and p<0.001, respectively). There is no statistical difference between route of antibiotic delivery for doxycycline (E) and ciprofloxacin (F). Resazurin (D), a dye that has been shown to have anti-\textit{Francisella} properties \textit{in vitro} failed to protect by either route.