deletions | additions       diff --git a/subsection_Mammalian_virulence_factors_are__.tex b/subsection_Mammalian_virulence_factors_are__.tex  index 29bf10c..2950803 100644  --- a/subsection_Mammalian_virulence_factors_are__.tex  +++ b/subsection_Mammalian_virulence_factors_are__.tex 
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  \subsection{Mammalian virulence factors are required for \textit{F. tularensis} virulence toward OS cockroaches}  In order to determine if virulence factors known to be required for \textit{F. tularensis} pathogenicity in mammals are also required in this model, we determined the LD_{50} value for several mutant strains of \textit{F. tularensis} LVS. Juvenile OS cockroaches were challenged by intrahemocoel injection followed by incubation at 37°C. Survival was monitored for 7 days post infection and the LD_50 value for each strain was determined by the method of Reed and Muench . \cite{REED}.  As shown in \textbf{Table 1}, loss of \textit{dsbA}, \textit{dipA}, \textit{iglC}, or \textit{deoB} significantly decreased virulence. These results correlate well with trends observed in mice \cite{24014665,25257164,23840797} and chick embryos \cite{18842136}. This suggests that significant overlap exists between the molecular determinants of disease across hosts from diverse phyla.