deletions | additions       diff --git a/subsection_Mammalian_virulence_factors_are__.tex b/subsection_Mammalian_virulence_factors_are__.tex  index c6f0d8d..ac98d8c 100644  --- a/subsection_Mammalian_virulence_factors_are__.tex  +++ b/subsection_Mammalian_virulence_factors_are__.tex 
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  \subsection{Mammalian \subsection{\textit{F. tularensis} genes required for  virulence factors in mammals also are  are required for\textit{F. tularensis}  virulence in OS cockroaches} In order to determine if virulence factors known to be required for \textit{F. tularensis} pathogenicity in mammals also are required in our cockroach model, we determined the LD_{50} value for several mutant strains of \textit{F. tularensis} LVS. Juvenile OS cockroaches were challenged by intrahemocoel injection followed by incubation at 37°C. Survival was monitored for 7 days post-infection and the LD_{50} value for each strain was determined by non-linear regression. As shown in \textbf{Table 1}, loss of \textit{dsbA}, \textit{dipA}, \textit{iglC}, or \textit{deoB} significantly decreased virulence. These results correlate well with trends observed in mice \cite{24014665,25257164,23840797} and chick embryos \cite{18842136}. These results suggest that significant overlap exists between the molecular determinants of disease across hosts from diverse phyla.