deletions | additions       diff --git a/subsection_Antibiotic_rescue_of_infected__.tex b/subsection_Antibiotic_rescue_of_infected__.tex  index bce3120..6a1f4e0 100644  --- a/subsection_Antibiotic_rescue_of_infected__.tex  +++ b/subsection_Antibiotic_rescue_of_infected__.tex 
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\subsection{Antibiotic rescue of infected OS cockroaches}  To explore whether OS cockroaches may be useful to model post-infection antibiotic treatment following \textit{F. tularensis} infection, we infected cockroaches with a high dose (3.4 x 10^{6} CFU) of \textit{F. tularensis} LVS by  intrahemocoel infection injection  and then administered antibiotics either by injection or by controlled feeding (\textbf{Figure 6}). As controls, cockroaches were either fed a sucrose solution or injected with PBS. All control cockroaches died by day 7 post-infection. Doxycycline, an antibiotic known to absorb well through mucus membranes, effectively prevented cockroach death when delivered by either route (statistics???). However, streptomycin and gentamicin, which have poor oral bioavailbility in mammals, were only effective at preventing cockroach death when injected directly into the hemocoel (80 percent survival with streptomycin; 90 percent survival with gentamicin). Ciprofloxacin failed to fully rescue OS cockroaches from LVS-induced death at the dose administered (1 ug per roach; 60 percent survival by ciprofloxacin injection; 50 percent survival by ciprofloxacin feeding), which may be due to differences in drug pharmacokinetics between insects and mammals. Finally, Resazurin, a dye molecule that has anti-\textit{F. tularensis} activity \textit{in vitro} \cite{24367766}, failed to protect OS cockroaches from infection (no survival by either delivery route).