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\subsection{Antibiotic rescue of infected OS cockroaches}  To explore whether OS cockroaches may be useful in the drug development pipeline, we infected cockroaches with a high dose (1.3 x 10^6 CFU to 3.4 x 10^{6} CFU) of \textit{F. tularensis} LVS by intrahemocoel injection and then administered antibiotics either by injection or by controlled feeding (\textbf{Figure 6}). All cockroaches in the vehicle only control groups died by day 7 post-infection (\textbf{Table 2}). Doxycycline, an antibiotic known to absorb well through mucus membranes, effectively prevented cockroach death when delivered by either route (\textbf{Table 2}, p<0.001). \textit{F. tularensis} LVS is resistant to azithromycin \cite{20416090}  and this antibiotic failed to protect OS cockroaches from infection, illustrating the specificity of protection in the assay (\textbf{Table 2}). Streptomycin and gentamicin, which have poor oral bioavailbility in mammals, were effective at preventing cockroach mortality when injected directly into the hemocoel (80 percent survival with streptomycin; 90 percent survival with gentamicin; p<0.001 for both antibiotics compared to no antibiotic treatment; \textbf{Table 2}). However, neither of these antibiotics rescued OS cockroaches when delivered by forced feeding perorally  (p=0.00199 for injection of streptomycin compared to forced feeding; p<0.001 for injection of gentamicin compared to forced feeding). Finally, Resazurin, an experimental drug candidate that has anti-\textit{F. tularensis} activity \textit{in vitro} \cite{24367766}, failed to protect OS cockroaches from infection (no survival by either delivery route; \textbf{Table 2}).