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\textbf{Figure 7. Rescue of OS cockroaches with antibiotics after lethal dose of \textit{F. tularensis LVS}.}
Kaplan-Meier survival curves Groups of OS cockroaches
(n=???) were infected with 3.4 x 10^6 CFU \textit{F. tularensis} LVS and treated with vehicle controls (A) or the indicated antibiotics (B-F) at 2, 48, and 96 hours post-injection. Solid blue lines
represent indicate groups treated with oral antibiotics. Dashed black lines
represent indicate groups treated by systemic injection. (A) Control groups
that were either injected with PBS or fed
the a sucrose solution without antibiotics all died within 7 days of infection. Streptomycin (B) and gentamicin (C)
only were protective when delivered systemically
(p=0.00199 and p<0.001, respectively), but not when delivered
orally (p=0.00199 and p<0.001, respectively). orally. There is no statistical difference between route of antibiotic delivery for doxycycline (E) and ciprofloxacin (F). Resazurin (D), a dye that has been shown to have anti-\textit{Francisella} properties \textit{in
vitro} vitro}, failed to
protect prevent cockroach death by either route.
Kaplan-Meier survival curves were compared by log-rank analysis.