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##Comparison to rooms with mechanical ventilation or open windows.  Kembel et al., 2012, compared 2012 \cite{Kembel_2012}, showed that  rooms in a health-care facility that were primarily ventilated via an open window had a lower proportion of known human pathogens than rooms that were mechanically ventilated. The only window on the ISS is never opened, and the doors are opened only briefly, every few months. So, we hypothesized that the proportion of human pathogens found on the ISS would be even higher than the mechanically ventilated rooms. To test this hypothesis, we obtained the list of known human pathogens compiled by Kembel _et al._, 2012, and followed their procedure to identify the proportion of OTUs in the ISS samples that were related to them (see Methods for details). Surprisingly, but reassuringly, we found that the ISS samples have a similar proportion of human pathogens to the mechanically ventilated rooms in the health-are facility (FigureKembel).