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Unlike the ISS, homes on Earth are exposed to a variety of sources of microbes, including the outside air, tracked-in soil, plants, and pets.   ##Comparison to the microbial communities of homes on Earth and belly buttons from the Human Microbiome Project  Because the ISS surfaces were significantly different from those found on surfaces in homes on Earth, and the dominant source of microbes on the ISS is presumably the human microbiome, we hypothesized that the microbial communities of the ISS surfaces might be more similar to human-associated microbial communities than Earth home surfaces. To test this hypothesis, we used the Belly Button microbiome as a proxy obtained 16S rDNA sequence data  for 100 random samples from each of 13 body sites from  the human microbiome. HMP Data Portal (http://hmpdacc.org/HM16STR/)\cite{Huttenhower_2012}\cite{Gevers_2012}.  The microbial communities associated with the ISS, Earth homes, and human belly buttons the HMP samples  were significantly different from each other (R2 (R^2  = 0.12, 0.08,  P < 0.001).