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\section{Introduction}
The fruit fly \emph{Drosophila melanogaster},
has a storied history of over a century as a model organism for genetic and behavioral studies. In more recent decades, it has also been used as a model organism for immune system and cardiac function, and it is emerging as a model for host-gut microbiome interactions. While Drosophila cardiac anatomy is quite different from that of a human, it does share some functionality (e.g., ion channels) and many of the genes involved in building a heart are shared between flies and humans.
\emph{Drosophila melanogaster} has also been a frequent flier to low Earth orbit, where it has been used to study the effects of spaceflight and microgravity on innate immunity \cite{Taylor_2014} \cite{Marcu_2011}, DNA mutation \cite{Vaulina_1982}, development \cite{Marco_1992} \cite{Abbott_1992}
As in humans, cardiac function declines over the life span of the fly. However, the typical lifespan of a fly is 45-60 days, allowing for
Transient adult microbiota, gut homeostasis and longevity: Novel insights from the Drosophila model. \cite{24983497}
Cardiac Proteome of Adult Drosophila melanogaster \cite{Cammarato_2011}
Drosophila, Genetic Screens, and Cardiac Function \cite{Wolf_2011}