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\item between different chains (paired domains in different homo-oligomers), i.e. the \textit{inter-chains distances}.   \end{enumerate}  \item We select only chains that have a given coverage of the domain, the backmapped part of the domain is over $ 60 \% $ of the alignment length.   \item In order to include only interacting homo-oligomers we filter out the ones that have an interaction surface under a given threshold (. threshold.  \end{itemize}  At the final step the database include 1372 pfam domains with 18839 TOT  PDB for a total of 111302 TOT  experimentally intra-chain structure units and 88631 TOT  inter-chains structure unit . To compare the DCA results with the inter-distance and the intra-distance, we take for each pfam domain the minimal distance across the individual PDB-chains-assembly distances, for both the intra-distances and the inter-distances. \\  Note that in the last case the distance matrices are not symmetric, dist(res1,res2) $\neq$ dist(res2,res1).