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On this point some remarks are necessary. For each pfam domain selected:  \begin{itemize}  \item We collect all PDB with a biological assembly that contain homo-oligomers of the pfam domain selected.  \item For each PDB we take into account repetitions of the domain inside the same chain and the different biological assemblies annotated. Finally one homo-oligomer domains pairing ( structure unit \textit{structure unit}  ) are identified unambiguously by :\\ Pfam ID, PDB ID, chain 1 ID , chain 2 ID, chain 1 domain number, chain 2 domain number, biological assembly number.\\  \item We create a map between the alignment positions and the 3D residues distances for each PDB ( \textit{backmapping} ). To do so we extract the minimal distances between the heavy atoms between residues in the domain:  \begin{enumerate} 
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