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The selection of the protein domain families are based on two main criteria :  \begin{itemize}  \item a statistical relevant sequence sample of the protein family, family i.e.,  the number of effective belonging sequences (similarity <0.8) greater than 500. \item the presence at least of one experimental solved structure by X-ray diffraction of a biological assembly with homo-oligomers (containing the domain) with a good resolution (< 3A \AN)   \end{itemize} 
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\item within the domains on the different chains, i.e. the \textit{intra-chains distances},   \item between different chains (paired domains in different homo-oligomers), i.e. the \textit{inter-chains distances}.   \end{enumerate}  \item We select only chains that have a given coverage of the domain, the  backmapped part of the domain it is  over $ 60 \% $. $ of the alignment length.  \item In order to include only interacting homo-oligomers we filter out the ones that have an interaction surface under a given threshold.  \end{itemize} 
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