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The selection of the protein domain families are based on two main criteria :  \begin{itemize}  \item a statistical relevant sequence sample of the protein family, the number of effective belonging sequences (similarity <0.8) greater than 500.   \item the  presence at least of one experimental solved structure by X-ray diffraction of a biological assembly with homo-oligomers (containing the domain) with a good resolution (< 3A \AN) \end{itemize}  Since the quaternary structure signals are likely to depends on the chains domains architecture, in order to be sure to include all the different biological assemblies that are experimentally at disposal we compare the DCA co-evolutionary signal with several PDB structures.\\ 
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