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\item between different chains (paired domains in different homo-oligomers), i.e. the \textit{inter-chains distances}.   \end{enumerate}  \item We select only chains that have a given coverage of the domain, the backmapped part of the domain is over $ 60 \% $ of the alignment length.   \item In order to include only interacting homo-oligomers we filter out the ones that have an interaction surface under a given threshold. threshold (intra chain contact density $<0.4$ .  \end{itemize}  At the final step the database include 1372 pfam domains with TOT PDB for a total of TOT experimentally intra-chain structure units and TOT inter-chains structure unit . 
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