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On this point some remarks are necessary. For each pfam domain selected:  \begin{itemize}  \item We collect all PDB with a biological assembly that contain homo-oligomers of the pfam domain selected.  \item For each PDB we take into account repetition of the domain inside the same chain and different biological assemblies annotated. At the end one homo-oligomer domains  pairing are identified unambiguously by \\ pfam ID, PDB ID, chain identifier 1, chain identifier 2, chain 1 domain number, chain 2 domain number, biological assembly identifier.\\  \item We create a map between the alignment positions and the 3D inter-residues distances for each PDB ( \textbf{backmapping} ) To do so we extract the minimal distances between the heavy atoms between residues in the domain:  \begin{enumerate} 
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