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Guido Uguzzoni edited section_Preliminary_Results_We_select__.tex
over 8 years ago
Commit id: 3ff3eaea50cf182f2b14596253c5f93ccc055be4
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Moreover the diversity in the architectures present within the domain families and the variety of possible inter-chain binding affect the magnitude between intra and inter domain co-evolutionary signals.
We can select the intra-chain false positive more reliable looking at the value of the DCA score. This is more significative than the absolute ranking of the couples when comparing different pfam.
In figure 8 are summarize the results of this analysis. Selecting the couples of residues based on the DCA scores the prediction rate are higher up to
$80\%$ true positive. $0.8$. On the other hand the families that have residue pairs with high DCA score and not in contact in the domain structures are not frequents (figure 9).
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