Guido Uguzzoni edited section_Preliminary_Results_We_select__.tex  over 8 years ago

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Moreover the diversity in the architectures present within the domain families and the variety of possible inter-chain binding affect the magnitude between intra and inter domain co-evolutionary signals.  We can select the intra-chain false positive more reliable looking at the value of the DCA score. This is more significative than the absolute ranking of the couples when comparing different pfam.   In figure 8 are summarize the results of this analysis. Selecting the couples of residues based on the DCA scores the prediction rate are higher up to $80\%$ true positive. $0.8$.  On the other hand the families that have residue pairs with high DCA score and not in contact in the domain structures are not frequents (figure 9).