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The selection of the protein domain families are based on two main criteria :  \begin{itemize}  \itemthere are  arelevant  statistical relevant sequences  sample ofprotein in  the family: protein family,  the number of effective belonging sequences (similarity <0.8) more greater  than 500. \item there is presence  at least a of one  experimental solved structure by X-ray diffraction of a biological assembly of with  homo-oligomers with a good resolution (< 3 \AN) \end{itemize}  The quaternary structure signals are likely to depends on the chains domains architecture.  
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