Matt Vassar edited figures/Table 4/caption.tex  almost 9 years ago

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After investigating the specific appraisal instruments as well as the particular components included in MQ/ROB evaluations, we wanted to examine how primary studies receiving low quality or high/unclear risk of bias determinations were incorporated into systematic review outcomes (Table 4). Out of the From  journals with a sample size greater more  than five, five systematic reviews, those published in  The British Journal of Ophthalmology included low MQ/high ROB primary studies in the estimation of summary effect sizes  more often  than any other with 68.18\% (15/22) of their reviews containing these studies. However, a subgroup, (15/22; 68.18\%); however, subgroup analysis,  meta-regression, and sensitivity analysis were conducted the least often in this same journal with only 18.18\% (4/22), 13.64\% (3/22), and 36.16\% (8/22) of their reviews performing these analyses, respectively. Ophthalmology followed with 58.70\% (27/46) of low MQ/high ROB studies included in their reviews. Investigative Ophthalmology and Visual Science excluded the largest percentage of studies (50.0\%; 3/6), and also conducted subgroup (33.33\%; 2/6), meta-regression (33.33\%; 2/6), and sensitivity analyses (66.67\%; 4/6) the most frequently. The British Journal of Ophthalmology (13.64\%; 3/22), JAMA ophthalmology (20.0\%; 1/5), and the American Journal of Ophthalmology (14.29\%; 1/7) all excluded a higher percentage of primary studies in their systematic reviews than the average percentage (12.64\%; 11/87) excluded across all journals. In more than 1/3 of their reviews, The American Journal of Ophthalmology (57.14\%; 4/7) and Ophthalmology (34.78\%; 16/46) had unclear statements on whether low MQ/high ROB were included. Sensitivity analysis was the performed most often in all journals (35.63\%; 31/87) while meta-regression was carried out the least (18.39\%; 16/87).