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\section{Method}  Photon counting imaging was performed with a dual mode cooled Hamamatsu C1790-13 EBCCD, with 512$\times$512 $512\times512$  pixels and 24$\times$24~$\mu$m $24\times24$~$\mu$m  pixel size. The EBCCD was cooled to -15$^\circ$C, and HiPic 7.1.0 software was used for image acquisition with 10~$\mu$s exposure time and super-high amplifier gain. The EBCCD was attached to the output port of an inverted Nikon Eclipse TE2000-E microscope, as schematically illustrated in Fig~\ref{fig1}a. For transmission imaging of a 1951 USAF resolution test chart (Fig~\ref{fig1}b), the microscope was used with a 4$\times$ 0.13NA air objective (Nikon) and a halogen lamp. For epifluorescence imaging, a cell sample (FluoCells Prepared Slide \#1, Molecular Probes) was excited with a pulsed 467 nm diode laser (Hamamatsu PLP-10) and imaged with a 100$\times$ 1.4NA oil objective (Nikon). The illumination intensity was adjusted such that single photon events could be observed (Fig~\ref{fig1}c,d).   %\subsection{Data processing}