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### Pharmacological studies  "Histamine H3 Receptor Regulates Sensorimotor Gating and Dopaminergic Signaling in the Striatum" \cite{26945087}.  ### Clinical and neuropsychological studies  Thresholds for externally applied sensory stimuli were similar in adults with "pure" TS and controls \cite{26818628}. These results, like those of a previous study \cite{22038938}, demonstrate that the sensory symptoms of TS are central in origin, suggesting abnormalities in interoceptive awareness or central sensorimotor processing.