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### Environmental risk factors
Researchers used data from the Avon Longitudinal Study of Parents and Children to identify maternal
psychological risk factors
during pregnancy that increase the risk of tic disorders in offspring \citep{Ben_Shlomo_2015}. The Avon Longitudinal Study is an ongoing, prospective, pre-birth cohort study of all children born in Avon, United Kingdom, between April 1, 1991, and December 31, 1992. Maternal questionnaires were administered throughout pregnancy and
they mothers also completed questionnaires about themselves and their children's development every 6 months from the child's birth to
the age
of 7 and then every year thereafter. In the final multivariate model, chronic maternal anxiety, evident both before and after
parturition, the child's birth, was associated with TS or chronic tic disorder in
their offspring. children. The authors suggest that this association may reflect shared genetic susceptibility or prenatal exposure.