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A study of 400 patients seen at a TS specialty clinic found that 39% had coprolalia and 20% had copropraxia \cite{26089672}. When the 222 patients with full comorbidity data were examined, only 13.5% had pure-TS. None of the pure-TS group had coprolalia and none had a family history of obsessive-compulsive disorder. In contrast, 39% of the group with comorbidities exhibited coprolalia. These researchers also found that individuals with complex tics were significantly more likely to report premonitory urges than individuals with simple tics.   Emotional regulation difficulties were described in several studies reminding us that TS patients often report that the tics are the least of their problems.  An experienced clinician who has done research on "rage attacks" in TS has provided a clinically useful summary of current knowledge \citep{Budman_2015}. Greater irritability was seen in TS adults with more severe tics and those with comorbid ADHD \cite{25716486}.  When 95 TS adults were compared with control subjects matched for sex, both men and women with TS had significantly higher scores for personal distress and gave themselves lower scores for their abilities to take other people's perspectives \cite{26144583}. In an important, large study of psychiatric comorbidity in TS, approximately 800 families were recruited primarily from TS specialty clinics in four different countries over a 16-year period \citep{25671412}. A total of 1374 participants with TS and 1142 family members unaffected by TS were included in the study. 86% of the TS participants had at least one psychiatric comorbidity and 72% had either OCD or ADHD. Other disorders, involving mood, anxiety or disruptive behavior, each occurred in approximately 30% of the TS participants. The genetic correlations between TS and mood was accounted for by ADHD and OCD, while ADHD alone accounted for the genetic correlations of TS with anxiety and disruptive behavior disorders. See also \citep*{Prime:Hirschtritt:2015}.