Cheryl Richards edited Phenomenology.md  about 8 years ago

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A retrospective review of 1,000,000 people in the Taiwan National Health Insurance Research Database examined the association between epilepsy with TS> 1062 children and adolescents with TS were identified. A group of 3186 without TS but matched on age and sex was used as a control group.The TS group had an 18-fold increased risk of epilepsy compared to the control group and even after adjusting for comorbidities (i.e., bipolar disorder, depression, learning difficulties, autism, anxiety disorder, sleep disorder), the risk of epilepsy was still 16-fold. Although the authors raise the issue that some tics may have been mistaken for seizures, they also suggest that TS children be followed closely for the development of epilepsy.  A study of 400 patients seen at a TS specialty clinic found that 39% had coprolalia and 20% had copropraxia (Eapen & Robertson, 2015are there distinct subtypes). When the 222 patients with full comorbidity data were examined, only 13.5% had pure-TS. 39% of the group with comorbidities exhibited coprolalia compared to 0% of the pure-TS group. The pure-TS group had no family history of obsessive-compulsive disorder. In addition, individuals with complex tics were significantly more likely to report premonitory urges than individuals with simple tics.  A small study of 17 male adolescents (Balottin et al., 2015) found that the only difference between the TS subjects and 51 age- and gender-matched controls on the Minnesota Multiphasic Personality Inventory-Adolescent was that the TS subjects scored significantly higher on the Obsessiveness Content Scale. In contrast a study of 50 TS adults in Germany used a variety of instruments to measure psychological symptoms and personality traits (Trillini & Muller-Vahl). Comorbidities were common with 41% having OCD, 28% being depressed and 26% having ADHD. Patients with OCD had more severe tics and there was a trend for those with ADHD to have more severe tics. Only 29% of the patients had no pathological personality traits. The demand-anxious trait was the most common personality trait (measured with the Inventory of Clinical Personality Accentuations) seen in patients and was present in 39% while histrionic personality traits were not found in any of the subjects. For patients without comorbidities personality traits were comparable to what was seen in the control group. Interestingly, ADHD did not contribute to increased probability of pathological personality traits. Although quality of life was affected by both personality traits and comorbidities, personality traits had a larger impact on quality of life.  Since tic suppression is part of Comprehensive Behavioral Intervention for Tics and Exposure and Response Prevention, there has been increased interest in investigating the characteristics of tic suppression and the factors that affect it. A study of 26 TS adolescents compared free ticcing with a tic suppression condition \citep{25786675}. During the free ticcing condition tic distribution across body parts was consistent with the general view that most tics occur at the level of the shoulders and above. Eye tics were the most frequent followed by facial/cervical tics. Limb tics and tics involving the trunk were the least common. During the tic suppression condition, an increase in eye tics were seen in 10 subjects along with an increase in hand tics in 3 subjects. Subjects were more successful inhibiting tics associated with the body parts that generally are involved in the fewest tics (such as the legs and the trunk). The authors make the case that tic suppression involves specific inhibition rather than global inhibition since tic suppression does not result in a general reduction in tics regardless of which body part they involve.