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Cheryl Richards edited Pathophysiology.md
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| Striatal D1- and D2-type dopamine receptors are linked to motor response inhibition in human subjects\citep{} |
"Stop-signal reaction time was negatively correlated with D1- and D2-type BP
ND in whole striatum, with significant relationships involving the dorsal striatum, but not the ventral striatum, and no significant correlations involving the continuous performance task." Compare also \citep{25562824}. |
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| Motor execution and motor imagery \cite{26566185}|
An exploratory study found neural hyperactivation for both types of tasks when TS adults were compared to controls. Interestingly, the exception to this was that basal ganglia and thalamic activation was smaller in the TS subjects than the controls. Premotor activation during the motor imagery tasks was correlated with tic severity. |
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| Sensorimotor cortex and insula are thinner in people with more premonitory sensory phenomena \citep{26538289}. | – |
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| Brain structural MRI in pediatric Tourette syndrome \citep{TSANIC:VBM:London} | – |
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| Electrophysiological similarities in Tourette syndrome and chronic tic disorder \citep{26531497} |
Event-related potentials recordings, during a stimulus-response compatibility task, revealed increased parietal and central activation for both patient groups compared to the control group. The two patient groups were not different from one another.|
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|Event-related topography and
the effect of comorbidities|
P300 amplitude in the frontal region was reduced for TS patients with comorbid symptoms compared to control subjects while a medication-naive TS group with no comorbid conditions was similar to the control group.