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A retrospective review of 1,000,000 people in the Taiwan National Health Insurance Research Database examined the association between epilepsy and TS \citep{26597416}. 1,062 children and adolescents with TS were matched on age and sex with a control group of 3,186 subjects. The TS group had an 18-fold increased risk of epilepsy compared to the control group; the risk was still elevated at 16-fold after adjusting for comorbidities (i.e., bipolar disorder, depression, learning difficulties, autism, anxiety disorder, sleep disorder). The authors acknowledge the possibility that some tics may have been mistaken for seizures, given the nature of the data set, but these data do suggest an important hypothesis for future confirmation.   In a large study of psychiatric comorbidity in TS, approximately 800 families were recruited primarily from TS specialty clinics in four different countries over a 16-year period \citep{25671412}. A total of 1374 participants with TS and 1142 family members unaffected by TS were included. 86% of the TS participants had at least one psychiatric comorbidity and 72% had either OCD or ADHD. Mood, anxiety and disruptive behavior disorders each occurred in approximately 30% of the TS participants. The genetic correlations between TS and mood were accounted for by ADHD and OCD, while ADHD alone accounted for the genetic correlations of TS with anxiety and disruptive behavior disorders.See also \citep*{Prime:Hirschtritt:2015}.  A study of 400 patients seen at a TS specialty clinic found that 39% had coprolalia and 20% had copropraxia \citep{26089672}. When the 222 patients with full comorbidity data were examined, only 13.5% had "pure" TS (i.e., without comorbidities). None of the "pure" TS group had coprolalia and none had a family history of obsessive-compulsive disorder. These results are consistent with previous findings that comorbid conditions need to be considered in clinical care and research on tic disorders.