deletions | additions       diff --git a/Pathophysiology.md b/Pathophysiology.md  index 26d3ed6..03404ca 100644  --- a/Pathophysiology.md  +++ b/Pathophysiology.md 
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Magnetoencehalography was used with adults while they were performing a Go/No-Go task \cite{26649991}. TS subjects showed less beta suppression in the sensorimotor region and increased beta power in the parieto-occipital brain geions that were contralateral to the hand used for the task. The TS subjects had less beta suppression while preparing to move their fingers and increased beta activity on the Go trials. Beta power was higher in TS patients than controls in the parieto-occipital area.  Local field potentials were studied in 3 patients who had DBS surgery \cite{25435514} along with EMG recordings to identify the muscle contractions associated with spontaneous tics. In all 3 patients repetitive thalamo-cortical coherent activity was present from 800 to 1500 msec prior to the muscle contraction related to spontaneous motor tics. The frequency range affected varied among the patients and there was also ongoing intermittent intra-thalamic coherences that were not synchronized to the tics suggesting that in TS. It was pointed out that DBS targets may not matter as much as the target is part of the striato-pallido-thalamo-cortical network. Since these patients were older and had very severe and complex tics, the authors mention that it is not clear at this point to what extent these results would generalize to the TS population as a whole.  | **Title** | **Comment** |