deletions | additions       diff --git a/Pathophysiology.md b/Pathophysiology.md  index 4ffcd7c..918f2de 100644  --- a/Pathophysiology.md  +++ b/Pathophysiology.md 
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The issue of how comorbidities affect a variety of measures was seen in a study of TS children and adolescents (Guller et al., 2015). Compared to age-matched controls the TS group did significantly worse on the parent-rated Social Responsiveness Scale which measures social impairment. They also significantly longer to complete forms of the Trail Making Tests. However, of the 31 TS subjects, 11 had OCD, 18 had ADHD and 9 had an anxiety disorder. Once these co-occurring conditions were taken into account the group differences on the Trail Making Tests and the Social Responsiveness Scale were no longer significant.  Many factors affect tic frequency. The role of attention on tic frequency was examined under several conditions (/citep{25185800}. In the first study mean tic frequencies were significantly higher for 12 TS subjects compared to baselines when they were alone in a room. Then they were recorded while looking at themselves in a mirror. A second study was performed to determine whether the increase in frequency was due to increased attention to the tics themselves or just due to increased self-awareness. In addition to the conditions from the first study the 16 subjects were also shown videos of themselves while they were not ticcing. Tic frequency was again lower during the baseline compared to the mirror condition. Tic frequency was lower when subjects were watching the video of themselves while not ticcing. The authors suggest that future treatments stressing attention to states when patients experience fewer tics.| – |  | **Title** – |   *Title**  | **Comment** | |:----------|:------------|  |  |  
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|   | The eyes have it \citep{26175694} | A measure of cognitive control explained half of the variance in tic severity. Blink rate—related to dopamine—was higher in children with TS than in controls. Pupil diameter—related to norepinephrine—was correlated to anxiety. |  | Electrophysiological similarities in Tourette syndrome and chronic tic disorder \citep{26531497} | – |  | Enhanced habit formation in Gilles de la Tourette syndrome Unmedicated TS subjects were compared with antipsychotic-medicated TS subjects and normal controls  \citep{26490329} | In an intrumental learning task, "unmedicated patients relied predominantly on habitual, outcome-insensitive behavioural control." This reliance was greater in patients with greater current tic severity. .  |