Cheryl Richards edited Treatment.md  about 8 years ago

Commit id: ae685d4133fbdad1d1b2cdba926760ad78aa49fe

deletions | additions      

       

2015 saw several practical advances in psychotherapeutic treatment for tics. [TicHelper.com](http://www.tichelper.com/) is a commercial adaptation of CBIT to the Internet, discussed at the [London congress in 2015](http://www.webcitation.org/6gWlBTYcC) \cite{Himle:TicHelper:London}. It is potentially an important treatment option, especially for the many TS patients who do not live near a behavior therapist. Efficacy testing is ongoing (see [ClinicalTrials.gov](https://www.clinicaltrials.gov/ct2/show/NCT02413216)).   A study of 124 children and adolescents with OCD and partial response to an adequate serotonin reuptake inhibitor compared response to treatment for children with tics compared to those without tics (Conelea et al, 2014). Children with tics were equally likely to respond to all treatment conditions and no more likely to terminate treatment prematurely or to be treatment-refractory.THIS WAS 2014 2014--IF WE ARE LEAVING IT IN, IT NEEDS MORE DETAILS ABOUT WHAT TREATMENT CONDITIONS WERE PROVIDED  \citet{25988365} dug into the data from 2 previously reported, pivotal, randomized controlled studies of behavior therapy for tics (CBIT) that together enrolled over 200 children and adults to address the question of which tics best predict treatment response to CBIT. Looking at specific tics across all subjects, the superior treatment benefit from CBIT compared to a control therapy could be attributed to differential improvement in only a few types of tics, including throat clearing and complex tics. However, tics that actually bothered people, most of which involved a premonitory urge, were more likely to respond preferentially to CBIT than to the control therapy. This result is not unexpected, since CBIT focuses first on bothersome tics, and preferably those preceded by a premonitory urge. This report also extends previous information about premonitory phenomena; about 40-60% of patients with any specific tic reported a premonitory urge for that tic.  "Living with Tics" is a modularized cognitive-behavioral treatment focused on decreasing  tic-related impairment and improving  quality of life (as opposed to focusing on tic severity and frequency _per se_), life. This treatment program was  recently tested in a random allocation, randomized,  waitlist control study \citep{25500348}. The \citep{25500348} with the  active intervention included including  up to 10 weekly sessions for children and adolescents. Treatment modules focused on a variety of themes includingtopics such as  self-esteem, emotion regulation, parent training, cognitive restructuring, coping at school, habit reversal training (limited to overcoming tic-related avoidance, and  1 or 2 sessions except for one subject who received 3 sessions) and overcoming tic-related avoidance. Those in the active of habit-reversal training. Active  treatment group had led to  improved self-rated quality of life and reduced (blinded) clinician-rated impairment of social, family or school/work function compared to the waitlist control group. An additional 7 waitlisted  youthfrom the waitlist group  then completed participated in  the treatment condition program  resulting in data on 19 participants for open-trial analyses. With the larger sample size the reduction inobsessive-compulsive symptoms and  tic severity (i.e., 30%) and obsessive-compulsive symptoms  was significant. Both the youth and their parents reported satisfaction with the intervention which is a reminder that improving quality of life can be a desired treatment goal. A small small,  uncontrolled open trial of mindfulness-based stress reduction was provided to 18 individuals who were at least 16 years old \citep{25149879}. Treatment consisted of 8 weekly 2-hour group classes and one four hour retreat. Participants wereencouraged  taught a tic-specific meditation exercise that involved noticing any urges to tic while maintaining a focus on one's breathing rather than trying to change or eliminate the urge to tic. Only one subject dropped out. Mean out and overall  tic severity was  decreased by 20% and for the participants who completed the program.  10 subjects were rated as "much improved" or "very much improved" and thus considered treatment responders and these responders. The  gains for the treatment responders  were maintained at a one month follow-up. An open label trial of psychotherapy using a cognitive psychophysiological model of tic behavior \cite{26250742} was  conducted with 102 adults with 49 who had  TS subjects and 36 subjects with or  chronic tic disorder completing treatment. The treatment consisted of disorder.  10 weeks of individual psychotherapy involved a variety of tasks components  including increasing awareness of tics, muscle discrimination, decreasing muscle tension and an overactive style of action, identifying low and high risk activities in terms of tic probability, highlighting the differences in behaviors, thoughts and feelings; decreasing perfectionistic beliefs linked to tension and relapse prevention. These psychotherapy tasks were chosen because of research suggesting that some TS subjects have perfectionist beliefs when they plan actions and this leads to an impulsive overactive style resulting in frustration, tension and tics. Large effect sizes were sen for both control groups compared to the waiting list control. 65% of the chronic tic disorder group and 74% of the TS group had reductions of more than 35% on the Tourette Syndrome Global Scale. At the end of treatment 78 of 85 completers were rated as mild or below regardless of the starting severity and the other 7 were considered to have moderate symptoms. Large effect sizes were seen whether they were simple or complex and similar results were seen for tic locations (i.e., eyes, face, head, neck and shoulder, trunk and abdomen, phonic). \citet{26022060} examined the effects of this psychotherapy approach on event-related potentials and lateralized readiness potentials (LRPs). EEGs were recorded for 20 TS subjects and 20 control subjects matched for age, sex and Raven Progressive Matrices score, while performing a stimulus-response compatibility inhibition task. During the NoGo condition, the TS group exhibited a delayed and overactivated frontal late positive component. The authors interpreted this result as evidence that this frontal activation may be an adaptive mechanism that allows patients to perform behaviorally similarly to the control subjects. TS subjects exhibited delayed stimulus-locked lateralized readiness potential onset latency. TS subjects also displayed larger response-locked LRP peak amplitudes which are associated with the execution of the motor program for the correct response. The authors suggest that the larger amplitudes may reflect overactivation of the pre-motor and motor cortex in TS patients. The larger sLRP amplitude was not normalized after psychotherapy. In contrast the sLRP onset and the rLRP peak were normalized after psychotherapy. Psychotherapy was provided for 124 children and adolescents who had OCD and had shown a partial response to a sertontin reuptake inhibitor \cite{26126872}. Tic status was evaluated using the YGTSS although tic duration could be less than a year. Tics were identified in 53% of the study participants and there were not significant differences from non-tic pariticipants in terms of age, six, family history, or OCD impairment or severity. Cognitive-behavioral therapy resulted in similar OCD symptom improvement in both groups.