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# Author contributions  ~~Both Both  authors contributed to all phases of this work and have agreed to the final content.~~ content.  # Competing interests  KJB: clinical trials supported by Psyadon Pharmaceuticals, Neurocrine Biosciences, Inc., and Acadia Pharmaceuticals; Acadia advisory board and speakers bureau. Both authors have received research funding from the Tourette Association of America.  # Grant information  This work was supported in part bythe  U.S. National Institutes of Health (NIH), (NIH)  grants K24 MH087913 and R21 NS091635, by a research grant from the Tourette Association of America, and by the McDonnell Center for Systems Neuroscience at Washington University. _The authors confirm that the funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The opinions expressed are the authors' and may not reflect the opinion of the funders._