deletions | additions       diff --git a/Pathophysiology.md b/Pathophysiology.md  index 10c14d7..c9fc9bf 100644  --- a/Pathophysiology.md  +++ b/Pathophysiology.md 
...
## Pathophysiology  ### Pathological studies    |**Citation** | **Title** | **Comment** |  |:------------|:----------|:------------|  | \citep{25561540} | Targeted ablation of cholinergic interneurons in the dorsolateral striatum produces behavioral manifestations of Tourette syndrome. | Discussed in \citep*{Richards_2014highlights}. |  | \citep{25185800} \citep{25735483}  | Visual feedback Astrocyte metabolism in TS | A collaborative genetic study shows association of TS with genes expressed in astrocytes, especially with 33 genes involved in glycolosis and glutamate metabolism. The results not only narrow the hunt for genes that may cause TS, they encourage future electrophysiological, imaging and pharmacological studies in a new direction. |   | \citep{25199956} | Transcriptome analysis  of own tics increases tic frequency the human striatum  in patients Tourette syndrome | This important study follows up on the autopsy results from the Vaccarino lab by comparing RNA transcripts from the basal ganglia of 9 TS and 9 matched control subjects. The most strongly associated set of downregulated transcripts involved striatal interneurons, consistent  with Tourette’s syndrome. the autopsy studies. The leading set of upregulated transcripts involved immune-related genes, suggesting activated microglia in the TS striatum. The authors conclude that the results "strongly [implicate] disrupted interneuron signaling in the pathophysiology of severe TS and suggests that metabolic alterations may be linked to their death or dysfunction." |  ### Neuroimaging  |**Citation** | **Title**  | – **Comment**  | |:------------|:----------|:------------|  | \citep{Greene_striatal_fcMRI} | Multivariate pattern classification of pediatric Tourette syndrome using functional connectivity MRI | – |  ### Clinical and neuropsychological studies  |**Citation**  | \citep{25199956} **Title**  | [Transcriptome analysis **Comment** |  |:------------|:----------|:------------|  | \citep{25185800} | Visual feedback  of the human striatum own tics increases tic frequency  in Tourette syndrome] patients with Tourette’s syndrome.  | – | | \citep{25193042} | Influence of gender on Tourette syndrome beyond adolescence | Pursues an unsolved clue about TS: Why are boys at higher risk? |  | \citep{25735483} | Astrocyte metabolism in TS | – |