deletions | additions       diff --git a/Treatment.md b/Treatment.md  index 2743efd..6182872 100644  --- a/Treatment.md  +++ b/Treatment.md 
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### Other treatment  |**Title** | **Comment** |  |:----------|:------------|An |An  open label trial of cranial electrical stimulation treatment was provided to 42 children, who were less than 12 years and had TS {Qiao et al}. The patients applied electrodes to their earlobes so that they could receive the treatment on a daily basis when they went to bed for 24 weeks. Treatment was provided for 60 minutes and they could go to sleep if they wanted. Only one child dropped out before the completion of the study. The mean YGTSS score significantly decreased from 26.3 when they were initially seen to 11.4 after 24 weeks of treatment. fMRI scanning was optional and only 8 subjects completed the scans before and after treatment. Independent component analysis with hierarchical partner matching was used to examine functional connectivity among regions within the cortico-striato-thalamo-cortical circuit followed by Granger causality to examine effective connectivity. After the CES treatment had stronger functional activity and connectivity in the anterior cingulate cortex, caudate and posterior cingulate cortex and weker activity in the supplementary motor area. Although these results are preliminary, an RCT with a larger sample size undergoing scanning before and after treatment (with appropriate controls for possible movement) certainly seems warranted.| |