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An experienced clinician who has done research on "rage attacks" in TS has provided a clinically useful summary of current knowledge \citep{Budman_2015}.  When 95 TS adults were compared with control subjects matched for sex, both men and women with TS had significantly higher scores for personal distress and gave themselves lower scores for their abilities to take other people's perspectives (Eddy et al. "Interpersonal reactivity differences in Tourette Syndrome"). \cite{26089672}.  In an important, large study of psychiatric comorbidity in TS, approximately 800 families were recruited primarily from TS specialty clinics in four different countries over a 16-year period \citep{25671412}. A total of 1374 participants with TS and 1142 family members unaffected by TS were included in the study. 86% of the TS participants had at least one psychiatric comorbidity and 72% had either OCD or ADHD. Other disorders, involving mood, anxiety or disruptive behavior, each occurred in approximately 30% of the TS participants. The genetic correlations between TS and mood was accounted for by ADHD and OCD, while ADHD alone accounted for the genetic correlations of TS with anxiety and disruptive behavior disorders. See also \citep*{Prime:Hirschtritt:2015}.