deletions | additions       diff --git a/Phenomenology.md b/Phenomenology.md  index 886d2e7..accb1d9 100644  --- a/Phenomenology.md  +++ b/Phenomenology.md 
...
## Phenomenology and natural history  Lifetime prevalence, age of risk, and genetic relationships of comorbid psychiatric disorders in Tourette syndrome \citep{25671412} | This is an important, large study of psychiatric comorbidity in TS. See our F1000Prime Recommendation \citep*{Prime:Hirschtritt:2015}. | Approximately 800 families were recruited primarily from TS specialty clinics in four different countries over a 16 year period. A total of 1374 participants with TS and 1142 family members unaffected by TS were included in the study. 86% of the TS participants had at least one psychiatric comorbidity and 72% had either OCD or ADHD. Other disorders, involving mood, anxiety or disruptive behavior, each occurred in approximately 30% of the TS participants.The genetic correlations between TS and mood was accounted for by ADHD and OCD while ADHD alone accounted for the genetic correlations between TS and anxiety and disruptive behavior disorders.   Total tic severity and vocal tic scores were significantly correlated with scores on the Premonitory Urge for Tics Scale and the University of Sao Paulo Sensory Phenomena Scale for TS adults (Kano "Sensory phenomena related to tics, obsessive-compulsive symptoms and global functioning"). The PUTS scores and the USP-SPS scores were correlated with the scores on the Dimensional Yale-Brown Obsessive-Compulsive Scale. In addition, PUTS scores and USP-SPS total scores were both significantly correlated with tic complexity and YGTSS vocal tic scores.  Influence of gender on Tourette syndrome beyond adolescence \citep{25193042} A follow-up study averaging 9 years of 75 TS patients, who had been seen at University-based clinic, found that reported TS impairment was more likely to decrease in males and increase in females. In addition, women were more likely than men to have more body regions, primarily the upper extremities, affected by tics in adulthood.  In an attempt to determine whether there are maternal psychological risk factors during pregnancy that increase the risk of tic disorders in offspring researchers used data from the Avon Longitudinal Study of Parents and Children (Ben-Shlmo et al., 2015). The Avon Longitudinal Study is an ongoing, prospective, pre-birth cohort study of all children born in Avon, United Kingdom between April 1, 1991 and Decmber 31, 1992. Maternal questionnaires were administered throughout pregnancy and they completed questionnaires about themselves and their children's development every 6 months from the child's birth to age 7 and then every year thereafter. In the final multivariate model, chronic maternal anxiety, which was seen both pre- and post-natally, was associated with the occurrence of TS and chronic tic disorders in their offspring. The authors suggest that this association may reflect shared genetic susceptiability or pre-natal exposure.