Cheryl Richards edited Pathophysiology.md  about 8 years ago

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|Dopamine receptors and motor response inhibition\citep{}|Stop-signal reaction time was negatively correlated with D1- and D2-type activation in the dorsal, but not ventral, striatum. No significant correlations involving the continuous performance task were found suggesting that different inhibitory mechanisms are involved in these two tasks. Compare also \citep{25562824}. |   |Motor execution and motor imagery \cite{26566185}|An exploratory study found neural hyperactivation for both types of tasks when TS adults were compared to controls. Interestingly, the exception to this was that basal ganglia and thalamic activation was smaller in the TS subjects than the controls. Premotor activation during the motor imagery tasks was correlated with tic severity. |  |  |Sensorimotor cortex and insula\citep{26538289}. |More insula\citep{26538289}|More  intense premonitory urges were associated with thinning in these areas.| |  TS classification\citep{Greene:Multivariate pattern classification}|Resting state functional connectivity was used to predict group membership for individual subjects.|  |Brain structural MRI in pediatric Tourette syndrome \citep{TSANIC:VBM:London} |A large multisite study found TS children had greater gray matter volume in the posterior thalamus and hypothalamus-midbrain in addition to decreased white mater volume in the orbital prefrontal cortex and the anterior cingulate.|  |  |Tourette syndrome and chronic tic disorder \citep{26531497} |Event-related potentials recordings, during a stimulus-response compatibility task, revealed increased parietal and central activation for both patient groups compared to the control group. The two patient groups were not significantly different from one another.|