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Baby videos provide a clue (Zappella et al., 2015) | 34 children in Italy were identified as having autistic behaviors in their second year of life. Families reported that development during the first year of life had been normal and they donated the videos that had been recorded before the age of 6 months. Videos of 18 boys were examined in detail. Abnormal general movements, which are spontaneously generated central pattern generators and modulated by more rostral brain regions, were seen 10 of the 11 boys who were eventually diagnosed with autism spectrum disorder between the ages of 3 and 7 years. In contrast, normal general movements were seen in the 8 boys who had autistic features. Interestinly, 7 of the 8 boys with transient autistic behaviors were later diagnosed with Tourette syndrome and 4 of the boys with autism spectrum disorder were diagnosed with TS as a comorbidity. These results, combined with the recent nearly ubiquitous availability of home baby videos in some cultures, suggest a pseudo-prospective study design to identify features predicting later development of TS.  Clinical features associated with an early onset in chronic tic disorders \citep{26596364} | "Early-onset The clinical characteristics of children who developed  TS was significantly associated before the age of 4 were compared  with an increased those who were older than 6. The younger group had a higher  rate of stuttering and stuttering,  other speech disfluencies as well as an increased rate of (e.g., speech initiation difficulties, speech prolongation), and  oppositional defiant disorder, symptoms disorder. There was no difference between the two groups in rate of ADHD or obsessive-compulsive symptoms. Interestingly, the early-onset group was more likely to have a mother with tics. The authors suggested  that often appear before this difference in onset  age 4. Early-onset TS was also linked might be related  to maternal transmission of tics." However, mother sensitivity to the child's symptoms resulting  inthis sample  tics starting before age 4 did not predict severity being diagnosed at a younger age, possible prenatal  or comorbid ADHD perinatal environmental factors or "maternally transmitted epigenetic modification  or OCD. | genomic imprinting which may be related to tic onset".  A retrospective review of 1,000,000 people in the Taiwan National Health Insurance Research Database examined the association between epilepsy with TS> 1062 children and adolescents with TS were identified. A group of 3186 without TS but matched on age and sex was used as a control group.The TS group had an 18-fold increased risk of epilepsy compared to the control group and even after adjusting for comorbidities (i.e., bipolar disorder, depression, learning difficulties, autism, anxiety disorder, sleep disorder), the risk of epilepsy was still 16-fold. Although the authors raise the issue that some tics may have been mistaken for seizures, they also suggest that TS children be followed closely for the development of epilepsy.