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KJB: clinical trials supported by Psyadon Pharmaceuticals, Neurocrine Biosciences, Inc., and Acadia Pharmaceuticals; advisory boards: Auspex (past) and Acadia; speakers bureau: Acadia. KJB is an (unpaid) member of the F1000Research Advisory Board. Both authors have received research funding from the Tourette Association.  # Grant information  This work was supported in part by the U.S. National Institutes of Health (NIH), grant grants K24 MH087913 and  R21 NS091635, by a research grant from the Tourette Association of America, and by the McDonnell Center for Systems Neuroscience at Washington University. _The authors confirm that the funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript._