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|**Title** | **Comment** |  |:----------|:------------|  | AADAC gene deletion \citep{26444075} | This large collaborative group studied _AADAC_, the gene encoding arylacetamide deacetylase, in which microdeletions had been identified in a previous, smaller copy number variation study. "In the Danish cohort, we identified eight patients with overlapping deletions of _AADAC_. Investigation of the additional five countries showed a significant association between the _AADAC_ deletion and GTS, and a final meta-analysis confirmed the significant association ( \( p = 4.4 \times 10^{−4} \) ); odds ratio = 1.9; 95% confidence interval = 1.33–2.71). Furthermore, RNA in situ hybridization and reverse transcription-polymerase chain reaction studies revealed that _AADAC_ is expressed in several brain regions previously implicated in GTS pathology." |  | NMDA receptor gene polymorphism in Han Chinese \citep{26321256} | This relatively small sample provided preliminary evidence for linkage of TS and the gene for the NMDA receptor 2B subunit. |