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# Competing interests  KJB participated in clinical trials supported by Psyadon Pharmaceuticals, Neurocrine Biosciences, Inc., and Acadia Pharmaceuticals, and was compensated by Acadia for advisory board and speakers bureau participation.Both authors have received research funding from the Tourette Association of America.  # Grant information  This work was supported in part by U.S. National Institutes of Health (NIH) grants K24 MH087913 and R21 NS091635, by a research grant from the Tourette Association of America, America to author CAR,  and by the McDonnell Center for Systems Neuroscience at Washington University. _The authors confirm that the funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The opinions expressed are the authors' and may not reflect the opinion of the funders._