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## Phenomenology and natural history  Lifetime prevalence, age of risk, and genetic relationships of comorbid psychiatric disorders in Tourette syndrome \citep{25671412} | This is an important, large study of psychiatric comorbidity in TS. See our F1000Prime Recommendation \citep*{Prime:Hirschtritt:2015}. | Approximately 800 families were recruited primarily from TS specialty clinics in four different countries over a 16 year period. A total of 1374 participants with TS and 1142 family members unaffected by TS were included in the study. 86% of the TS participants had at least one psychiatric comorbidity and 72% had either OCD or ADHD. Other disorders, involving mood, anxiety or disruptive behavior, each occurred in approximately 30% of the TS participants.The genetic correlations between TS and mood was accounted for by ADHD and OCD while ADHD alone accounted for the genetic correlations between TS and anxiety and disruptive behavior disorders.    | **Title** | **Comment** |  |:----------|:------------|  |Lifetime prevalence, age of risk, and genetic relationships of comorbid psychiatric disorders in Tourette syndrome \citep{25671412} | This is an important, large study of psychiatric comorbidity in TS. See our F1000Prime Recommendation \citep*{Prime:Hirschtritt:2015}. | Approximately 800 families were recruited primarily from TS specialty clinics in four different countries over a 16 year period. A total of 1374 participants with TS and 1142 family members unaffected by TS were included in the study. 86% of the TS participants had at least one psychiatric comorbidity and 72% had either OCD or ADHD. Other disorders, involving mood, anxiety or disruptive behavior, each occurred in approximately 30% of the TS participants.The genetic correlations between TS and mood was accounted for by ADHD and OCD while ADHD alone accounted for the genetic correlations between TS and anxiety and disruptive behavior disorders.  | Influence of gender on Tourette syndrome beyond adolescence \citep{25193042} A follow-up study averaging 9 years of 75 TS patients, who had been seen at University-based clinic, found that reported TS impairment was more likely to decrease in males and increase in females. In addition, women were more likely than men to have more body regions, primarily the upper extremities, affected by tics in adulthood.   |Attention and tic suppression in TS \citep{25486384} | – |   | "Rage attacks" in TS \citep{Budman_2015} | A summary of current knowledge on this clinically important topic, from the expert. |